Latest Science on Sarcopenia
Why Preventing Sarcopenia is Anti-Ageing?
How To Reverse and Prevent Sarcopenia?
Sarcopenia: Executive Summary
As people get older, they often experience a decrease in muscle strength and balance called sarcopenia. This condition is connected to lower bone mass and strength, and can have serious effects on older adults, including frailty, falls, and a higher risk of health issues like insulin resistance and rheumatoid arthritis.
Sarcopenia can also lead to a reduced ability to do everyday tasks, loss of independence, and the need for long-term care.
The progression of sarcopenia is influenced by factors like exercise, diet, sleep, activity levels, and mental attitude. Research has shown that maintaining muscle mass and strength is important for a person’s health, well-being, and longevity.
In fact, regular exercise and a healthy lifestyle can help to slow down the decline in muscle mass and strength as we age.
Sarcopenia and bone loss are closely related, and both can negatively impact the quality of life for seniors. These conditions also come with a significant financial burden.
More muscle mass is linked to a longer life, and engaging in muscle-strengthening exercises can increase life expectancy.
It’s important to prioritize muscle strength at any age but the risks of muscle loss increase as we age.
Our muscles account for more than half of our body mass and play a crucial role in our overall health. Losing muscle mass can contribute to poor health outcomes, fatigue, loss of function, and increased risk of falls and frailty.
Regular exercise is key to preventing age-related health problems. A combination of exercise and certain supplements can be beneficial for maintaining muscle mass and strength, even as we grow older.
The Body supplement works best when paired with regular physical activity. By making healthy lifestyle choices and using the Body supplement, older adults can enjoy improved well-being, memory, and cognition, potentially leading to increased longevity.
Studies showing the consequences of age-related
disease such as sarcopenia
and osteo-arthritis
Sarcopenia is an age-related disease affecting 10%-16% of elderly individuals worldwide (Petermann-Rocha et al., 2022).
The consequences in older adults of Sarcopenia can be severe, the strength and function of decline associated with the condition can in turn contribute to a number of adverse health outcomes, these include frailty mobility falls loss of increased, increased insulin resistance and even rheumatoid arthritis (Larsson et al., 2019)
Sarcopenia can significantly impact a person's quality of life, reducing their ability to perform daily tasks, and leading to a loss of independence and the need for long-term care (Cleveland Clinic medical professional, 2022).
Sarcopenia is linked to various negative health outcomes, such as physical disability, nursing home admission, depression, hospitalization, and even death (Beaudart et al., 2014).
Research shows a correlation between increased muscle mass, strength, stamina, and longevity. Ageing can impair muscle growth, leading to a decline in muscle mass and strength, which is associated with higher mortality rates in elderly individuals. Maintaining healthy muscle mass through exercise or protein-based nutrition improves health, independence, and functionality (McLeod et al., 2016).
It has been reported that those older adults with sarcopenia have a two-fold risk for hospitalization and significantly higher hospital stays than those without sarcopenia, increasing $375 the cost per person by and having an annual marginal increase of $2315 (Álvarez-Bustos et al., 2022).
Increasing disability as a consequence of Sarcopenia may lead to loss of independence and the need for long-term care (Cleveland Clinic medical professional, 2022).
Many consequences of sarcopenia are the development of physical disability, nursing home admission, depression, hospitalization, and even mortality (Beaudart et al., 2014).
Individuals with sarcopenia, defined as the loss of muscle mass and muscle strength, may have a 60% increase in the relative risk of death compared to people without sarcopenia (Zhang et al., 2018).
Sarcopenia and osteopenia, or bone loss, are closely related, with both conditions contributing to diminished quality of life in seniors (Cruz-Jentoft et al., 2010); (Janssen et al., 2002); (Landi et al., 2012); (Drootin, 2011).
Osteoarthritis is a condition that significantly impacts quality of life (Clyns et al., 2019).
Osteoarthritis pain can lead to immobility, decreased functional performance, and the development of sarcopenia (Basat et al., 2021).The annual cost of hospitalization for individuals with osteoarthritis in North America shown in a study in 2022 was $14,000 and the indirect costs per year were $6,500 (Goates et al., 2019).
Muscle mass is inversely associated with risk of death (Abramowitz et al., 2018),
A 2021 review found that engaging in 30-60 minutes of muscle-strengthening exercise per week increased life expectancy by 10-17% (Skolnik, 2022)
Regular aerobic exercise/physical activity and high cardiorespiratory fitness are associated with a reduced incidence of several chronic diseases (i.e., cardiovascular diseases, type 2 diabetes and some types of cancer), which may increase life expectancy (Ciolac, 2013).
Revitalize Your Life Defy Aging Invigorate Your Body
Experience a Radiant, Energetic Lifestyle
Discover our Body Supplement
The Body supplement
Proprietary molecular biology research has enabled Revitaceuticals LLC to create the first sports supplement specifically formulated for the active over 45s. The supplement “Body” turbocharges the level of benefits that can be achieved by exercise and diet alone.
Notwithstanding normal effects of ageing “Body” facilitates the over 45s:
- To be capable of greater effort in Exercise.
- Reduces the time it takes for muscles to recover from exercise.
- Makes the muscles stronger
- improves stamina
- Increases muscle mass to make an ageing adult look younger
Synergistic compounds in the Body”supplement
The body supplement contains two synergistic amino acids and one amino acid derivative in the appropriate generous dosage for the over 45s. Our research has shown these three ingredients work wonders for the active over 45-year-old and works even for 80 year old adults.
These compounds are:
- Creatine monohydrate
- Glycine
- Beta Alanine
Summary of the health benefits
of each compound in the Body
supplement
Creatine monohydrate
Creatine is a well-studied nutritional ingredient which the body itself produces. Creatine is commonly used by both recreational and professional athletes. It has also gained interest in anti-aging and life extension communities.
Our bodies mainly produce creatine in the liver and kidneys, and it’s stored mostly in our skeletal muscles and brain. Creatine plays a crucial role in producing and recycling ATP, which is the body’s primary energy source.
Creatine monohydrate (CrM) is often considered the gold standard of creatine supplements due to its high bioavailability, stability, low cost, and proven safety and effectiveness. CrM can act as an energy buffer, protecting the body’s ATP levels.
The benefits of creatine are wide-ranging, from protecting against cognitive decline and heart failure to reducing insulin levels and preventing muscle loss.
Creatine enhances mitochondrial function, which helps combat the effects of aging. When used alongside exercise, it may be an effective strategy to fight age-related muscle loss and sarcopenia.
CrM supplementation has been reported to improve exercise performance, particularly in high-intensity exercise, and enhance training adaptations in people of all ages, including adolescents, young adults, and older individuals.
The benefits of creatine for older adults can improve their quality of life and potentially reduce the burden of diseases related to muscle loss and cognitive dysfunction.
Creatine also enters the cell’s mitochondria, where it can help reduce the production of reactive oxygen species (ROS), acting as an antioxidant.
Notwithstanding normal effects of ageing “Body” facilitates the over 45s:
- Creatine has been receiving great interest on antiaging and life extension communities (Gonzalez, 2021).
- Typically we produce an average around one gram of creatine by day and most goes on to be stored as forceful creatine primarily in skeletal muscle about 95%, but also in our brain (Cooper et al., 2012).
- Triphosphate (ATP) concentration (Clark, 1997).
- Creatine may be an effective dietary strategy to combat age-related muscle atrophy and sarcopenia when used to complement the benefits of exercise training (Dolan et al., 2019).
- Creatine supplementation has been reported to improve acute exercise performance particularly in intermittent high-intensity exercise bouts as well as enhance training adaptations in adolescents young adults, and older individuals (Kreider et al., 2022).
- The benefits afforded to older adults through creatine ingestion are substantial, can improve quality of life, and ultimately may reduce the disease burden associated with sarcopenia and cognitive dysfunction (Rawson & Venezia, 2011).
Glycine
Glycine offers several health benefits, such as helping to regulate sleep and our internal body clock. This amino acid has a calming effect on the brain, making it easier for people to relax and get ready for sleep.
Sleep is crucial for removing toxins and repairing brain cells damaged by free radicals.
Like some prescription sleep medications, glycine helps regulate body temperature, which can promote better sleep.
Adding more glycine to your diet might also support cartilage regeneration by boosting collagen production, which could help treat and prevent osteoarthritis.
Additionally, taking glycine supplements can increase the production of glutathione, an antioxidant that helps reduce oxidative stress in older adults.
Beta Alanine
Beta-alanine helps muscles by potentially increasing muscle carnosine content by 60-80% in healthy young adults, which improves their ability to perform high-intensity exercise.
Research suggests that it can also enhance exercise performance in older adults. Having a high muscle carnosine content may provide both immediate and long-term benefits, encouraging individuals to maintain an active lifestyle.
Beta-alanine supplementation is a proven dietary intervention that could help delay age-related muscle function decline.
- A Healthy Aging Study suggests that beta-alanine also improves exercise in older adults (Culbertson et al., 2010).
Antiaging pharmacological action of each active component in the “Body” supplement
Creatine
Creatine is mainly stored in the muscles, with about 95% found there. Creatine monohydrate (CrM) has high bioavailability, stability, and numerous studies proving its effectiveness and safety.
The effect of creatine supplementation on muscle mass or strength suggests that it may be most beneficial when paired with resistance training.
Creatine monohydrate supplementation, particularly when combined with resistance training, can be an effective lifestyle intervention to improve muscle mass, strength, and also every day functionality in older adults.
Creatine may help maintain and even enhance cognitive function as we age, providing a potential protective effect against age-related cognitive decline.
Most brain disorders involve a disruption of the brain’s energy supply systems, this applies not only to chronic age-related diseases such as Parkinson’s and Alzheimer’s but also to acute conditions such as strokes and traumatic brain and spinal cord injuries.
This disruptive energy loss leads to over accumulation of damaging lipofuscin pigments, often seen as dark patches in aging adults skin. Lipofuscin is a recognized marker of Ageing and not only is it negatively associated with longevity.
Unfortunately, lipofuscin naturally accumulates as we age, and this is the very same unwanted pigment that’s building up in our brain and other organs with every passing decade.
Daily Creatine supplementation has been shown to lower the accumulation of damaging lipofuscin Creatine has thus been shown to have neuroprotective properties, which may help reduce the risk of neurodegenerative diseases and support overall brain health.
- it is shown that creatine monohydrate supplementation, primarily when combined with resistance training, is a viable lifestyle intervention to improve aging muscle mass, strength and measures of functionality, which may decrease the risk of falls and fractures in older adults. The combination of creatine and resistance training has some beneficial effects on aging bone. (Candow et al., 2022).
- Creatine supplementation can significantly increase muscle creatine levels. Increasing muscle creatine not only will improve training but also the performance of daily activities (Wu et al., 2022).
- Creatine has been shown to improve cognitive performance, particularly in tasks that require short-term memory and quick thinking (Rae et al., 2003).
- Studies have found that creatine supplementation can lead to improvements in cognitive tasks such as serial subtraction, random number generation, and Raven’s Progressive Matrices, among others (McMorris et al., 2007).
- Studies have found that creatine can protect against neuronal damage caused by various stressors, such as oxidative stress, mitochondrial dysfunction, and excitotoxicity (Bender et al., 2005).
- Additionally, creatine has been shown to improve mitochondrial function and reduce oxidative damage in animal models of neurodegenerative diseases such as Parkinson’s and Huntington’s disease (Matthews et al., 1999.
- These neuroprotective effects may help to slow down the progression of age-related neurodegenerative diseases and maintain brain function Klivenyi et al., 2004).
- 3. Creatine slow brain aging
- Research shows that Creatine is an important nutrient for maintaining brain function in both healthy people and those suffering from brain related diseases such as dementia, for example brain neurons are extremely sensitive to diminished ATP levels so with creatine recognizes one of the most effective nutritional supplements for Maintaining or raising ATP supplementation in later life in order to help maintain healthy brain function may well prove to be a smart strategy (Roschel et al., 2021).
- Daily Creatine supplementation has been shown to lower the accumulation of damaging lipofuscin (Roschel et al., 2021).
- Many studies indicate that Creatine supplementation show great promise with regard to controlling and potentially helping prevent type 2 diabetes (Kreider et al., 2017).
- Many studies indicate that creatine may have efficacy as an antidepressant which although very encouraging will require further studies before we can reach any firm conclusions (Kious et al., 2019).
it is shown that creatine monohydrate supplementation, primarily when combined with resistance training, is a viable lifestyle intervention to improve aging muscle mass, strength and measures of functionality, which may decrease the risk of falls and fractures in older adults. The combination of creatine and resistance training has some beneficial effects on aging bone.
Creatine supplementation can significantly increase muscle creatine levels. Increasing muscle creatine not only will improve training but also the performance of daily activities (Wu et al., 2022).
Creatine has been shown to improve cognitive performance, particularly in tasks that require short-term memory and quick thinking (Rae et al., 2003).
Studies have found that creatine supplementation can lead to improvements in cognitive tasks such as serial subtraction, random number generation, and Raven’s Progressive Matrices, among others (McMorris et al., 2007).
Studies have found that creatine can protect against neuronal damage caused by various stressors, such as oxidative stress, mitochondrial dysfunction, and excitotoxicity (Bender et al., 2005).
Additionally, creatine has been shown to improve mitochondrial function and reduce oxidative damage in animal models of neurodegenerative diseases such as Parkinson’s and Huntington’s disease (Matthews et al., 1999
These neuroprotective effects may help to slow down the progression of age-related neurodegenerative diseases and maintain brain function
Glycine
Glycine may improve memory and learning in older adults, and is necessary for rebuilding collagen, which declines as we age. This is particularly important in conditions like osteoarthritis, which affects a large percentage of older individuals.
Increasing glycine in the diet could help with cartilage regeneration by enhancing collagen synthesis, potentially contributing to the treatment and prevention of osteoarthritis.
Glycine supplementation has some of the blood-thinning benefits of aspirin, without the side effects, including reduced platelet aggregation, increased bleed time, improved microcirculation, and reduced inflammation.
Glycine is therefore potentially beneficial in preventing diseases where increased platelet aggregation and thrombosis are involved, such as cardiovascular disease and stroke.
Diets high in glycine have been observed to lead to a small increase in lifespan in rodents, an effect similar to the lifespan extension seen in diets low in methionine.
Beta Alanine
Beta-alanine is a well-researched sports supplement known for its antioxidant, immune-enhancing, and anti-aging properties. It helps increase exercise capacity and decrease muscle fatigue, making it a valuable supplement for athletes.
Beta-alanine serves as a building block for carnosine, a molecule that helps reduce acidity in muscles during high-intensity exercise. This allows individuals to exercise longer before experiencing fatigue. Carnosine also has antioxidant properties and may affect aging. To experience the benefits of beta-alanine, it should be taken 30-45 minutes before exercising.
While beta-alanine has positive effects on stamina, there is no direct link to changes in testosterone levels. Research has shown that beta-alanine supplementation can improve exercise capacity and cognitive function in older adults.
Ingesting beta-alanine daily for ten weeks has been found to improve functional performance, increase strength, and delay fatigue in older individuals, making it a safe and beneficial supplement for this age group.
- Researchers found that beta-alanine supplementation increased exercise capacity and inhibited declines in executive brain function caused by post-endurance exercise fatigue in study participants over the age of 50 (Furst et al., 2018); (Menayang, 2018).
- Studies in older adults have shown that daily beta-alanine ingestion for ten weeks can improve functional performance, boost strength levels, and delay fatigue. Beta-alanine has also been associated with improved cognitive function in older adults (Furst et al., 2018); (Menayang, 2018).
Become a Partner with Revitaceuticals:
Empower Your Clients to "Live Better Longer"
About Us
Revitaceuticals has spent the last two years conducting a molecular biology research project to identify naturally occurring biochemicals with proven health and anti-aging benefits for those over 40.
Our first supplement for resale, “Body,” fills a critical gap in the sports supplement market by catering specifically to individuals aged 45 and older.
These biochemicals work at the cellular level to increase the likelihood of postponing age-related diseases, thereby promoting longevity.
Supplementing these biochemicals in conjunction with good lifestyle practices provides significant health and anti-aging benefits when compared against placebo and control groups.
Revitaceuticals’ supplements are the result of this groundbreaking research project.
Our Mission
Many people understand that exercise, diet, and a balanced lifestyle can help them live healthier, longer lives. However, committing to and maintaining such a lifestyle can be challenging and the majority of people are disinclined to work now to prevent what they believe may never happen. However, the data is clear, a sedentary lifestyle brings with it a high probability of age-related serious even life-threatening disease. It makes sense to take on precautionary measures now because the alternative of disease and the consequent lower quality of life becomes far more expensive, distressing and challenging.
Mainstream medicine often fails to consider prevention or proactive health improvements because it is part of a system that is inherently reactive. It relies on the sale of expensive and potentially harmful prescription drugs with significant side effects.
At Revitaceuticals our mission is to help people maintain and improve their quality of life as they age. We do this primarily through research and the formulation of natural molecular anti aging supplements.
- Dr Milton, MSc, PhD
- Director of research
- Revitaceuticals LLC
Revitaceuticals is excited to extend an invitation to healthcare and fitness professionals to join our partner program as an approved reseller of our innovative, natural anti-aging supplement program, “Live Better Longer.”
Designed specifically for individuals aged 45 and older, our supplements are backed by proprietary molecular biology research, providing targeted support for improved quality of life.
Why Become an Approved Reseller?
As an approved reseller, you will enjoy several benefits, including:
- A personalized sales website provided at no cost to you
- Complimentary promotional give-away samples of our unique natural anti-aging supplements
- zero-cost option
- Monthly profit from sales and ongoing commissions from repeat customers
Two Approved seller options
Zero cost option
you commit to nothing and pay nothing, your customers buy off your website, you introduce your patients/clients, earn 15% commission on all sales through your website.
Become a stockist
you order stock and depending upon volume can earn between 25% and 40% markup to the recommended retail selling price. You receive zero cost samples to give away. You will be listed on our website as an official Revitaceuticals reseller.
Upon submitting your application, you may be approved as an approved reseller. If accepted into the program, you can proceed or cancel whenever you wish. If you are not sure whether you wish to become a stockist, start with zero cost option and once you see you can sell, you can upgrade to become a stockist at any time.
Our first supplement for resale, "Body," fills a critical gap in the sports supplement market by catering specifically to individuals aged 45 and older.
Traditional sports supplements focus on young bodybuilders and do not address the unique biological needs of older adults.
Our molecular biology research has enabled us to create a ground-breaking supplement that offers scientifically-proven anti-aging benefits for the mature adult.
How to Apply:
Upon completing your application, we will notify you of your acceptance. Additionally, we will share information on the upcoming and exciting anti-aging supplements in development.
We are delighted that you wish to Join us on this journey to help your clients “Live Better Longer” with Revitaceuticals. Before our launch, you will be asked to confirm whether or not you still wish to join our reseller network.
To apply for our approved reseller program, please complete the two-part form below. The form will guide you through both sections, and your data will be securely sent to our email and database for review.